Murtaza, N and Baboota, RK and Jagtap, S and Singh, DP and Khare, P and Sarma, SM and Podili, K and Alagesan, S and T. S. Chandra, TS and K. K. Bhutani, KK and Boparai, RK and Bishnoi, M and Kondepudi, KK (2014) Finger millet bran supplementation alleviates obesity-induced oxidative stress, inflammation and gut microbial derangements in high-fat diet-fed mice. British Journal of Nutrition, 112 (09). pp. 1447-1458. ISSN 0007-1145

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Abstract

Several epidemiological studies have shown that the consumption of finger millet (FM) alleviates diabetes-related complications. In the present study, the effect of finger millet whole grain (FM-WG) and bran (FM-BR) supplementation was evaluated in high-fat diet-fed LACA mice for 12 weeks. Mice were divided into four groups: control group fed a normal diet (10 % fat as energy); a group fed a high-fat diet; a group fed the same high-fat diet supplemented with FM-BR; a group fed the same high-fat diet supplemented with FM-WG. The inclusion of FM-BR at 10 % (w/w) in a high-fat diet had more beneficial effects than that of FM-WG. FM-BR supplementation prevented body weight gain, improved lipid profile and anti-inflammatory status, alleviated oxidative stress, regulated the expression levels of several obesity-related genes, increased the abundance of beneficial gut bacteria (Lactobacillus, Bifidobacteria and Roseburia) and suppressed the abundance of Enterobacter in caecal contents (P≤ 0·05). In conclusion, FM-BR supplementation could be an effective strategy for preventing high-fat diet-induced changes and developing FM-BR-enriched functional foods.

Item Type:	Article
Uncontrolled Keywords:	Obesity; Inflammation; Finger millet; Gut microflora; Prebiotic effects
Subjects:	Food Science and Technology Nutrition Science and Technology
Depositing User:	Dr. Author @NABI
Date Deposited:	06 Jun 2015 07:50
Last Modified:	06 Jun 2015 07:50
URI:	http://nabi.sciencecentral.in/id/eprint/14

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