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Bishnoi, M and Khare , P and Brown, L and Panchal , SK (2018) Transient receptor potential (TRP) channels: a metabolicTR(i)P to obesity prevention and therapy. Obesity Reviews, 19 (9). pp. 1269-1292. ISSN 1467-789X
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Abstract
Cellular transport of ions, especially by ion channels, regulates physiological func-tion. The transient receptor potential (TRP) channels, with 30 identified so far, arecation channels with high calcium permeability. These ion channels are present inmetabolically active tissues including adipose tissue, liver, gastrointestinal tract,brain (hypothalamus), pancreas and skeletal muscle, which suggests a potential rolein metabolic disorders including obesity. TRP channels have potentially importantroles in adipogenesis, obesity development and its prevention and therapy becauseof their physiological properties including calcium permeability, thermosensationand taste perception, involvement in cell metabolic signalling and hormone release.This wide range of actions means that organ-specific actions are unlikely, thus in-creasing the possibility of adverse effects. Delineation of responses to TRP channelshas been limited by the poor selectivity of available agonists and antagonists. Foodconstituents that can modulate TRP channels are of interest in controlling meta-bolic status. TRP vanilloid 1 channels modulated by capsaicin have been the moststudied, suggesting that this may be the first target for effective pharmacologicalmodulation in obesity. This review shows that most of the TRP channels are poten-tial targets to reduce metabolic disorders through a range of mechanisms.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | adipocytes, energy expenditure, obesity, transient eceptor potential channel |
| Subjects: | Food Science and Technology Nutrition Science and Technology |
| Depositing User: | Dr. Author @NABI |
| Date Deposited: | 12 Mar 2021 05:05 |
| Last Modified: | 12 Mar 2021 05:05 |
| URI: | http://nabi.sciencecentral.in/id/eprint/58 |
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